I say BGE.
Colts don't have much of a running game. On top of that, Houston is going to stack the box to make double sure they can't run or do short dump offs to the backs. They want to put the game on Collins, an old man that has only had a couple weeks to learn the Colts offense. They want to try to force him to throw down the field.
10 team, PPR, 1 qb 1rb, 2wr, 2flex (rb/wr/te), 1k, 1dst
QB: Stafford, E. Manning
RB: Peterson, Blount, Hightower, Starks, Tate, Tolbert
WR: Nicks, Wayne, Bowe, S. Johnson, M. Thomas