I would take Charles/Romo.
I think Vick is going to take a step down this year. The OL is not nearly as good as last year and is not going to give him the protection he needs.
Charles is a definite upgrade over Moreno. McGahee is going to steal most of the TDs away from Moreno.
10 team, PPR, 1 qb 1rb, 2wr, 2flex (rb/wr/te), 1k, 1dst
QB: Stafford, E. Manning
RB: Peterson, Blount, Hightower, Starks, Tate, Tolbert
WR: Nicks, Wayne, Bowe, S. Johnson, M. Thomas