Hightower and Wayne is a good choice, for the reasons people stated above. But I do think Houston will 'try' to shut him down with J. Joseph, who's a lot better than people take him for, and I dunno if with Collins you can still consider Wayne a WR1. Brandon Marshall on the other had has been impressive in the preseason and will be looking to bounce back after last year's disappointment. Plus Chad Henne throws to him A LOT.
I would go with Marshall and Wayne. Both teams will be playing from behind all game, and Henne and Marshall have a good connection going already. Wayne is proven for being able to catch the ball, even if they put J. Joseph on him all game, Wayne is known for comeback routes. I am not sold on Hightower taking the bulk of the carries in Shanahan's system. He usually mixes things up, and with Torrain in that backfield, who proved himself worthy last year, i think they go more RBBC early this season to see who develops in that system.