Tough one...I'd go with Pierre Thomas. Tougher matchup but I believe he'll have a larger number of carries and receptions to make up for it.
QB: Drew Brees, Matthew Stafford
RB: Adrian Peterson, Peyton Hillis, Steven Jackson, Jackie Battle
WR: Andre Johnson, Roddy White, Dez Bryant, Steve Smith, Vincent Jackson
TE: Vernon Davis, Tony Gonzalez
K: John Kasay
D/ST: Cincinnati Bengals