I wouldn't. You already seem pretty well set at RB and I think that would expose you at WR. Harvin's QB is questionable, Lloyd's hurt and I don't think Foster's hamstring is 100%.
Take it with a grain of salt though, this is my first year playing.
Any thoughts: viewtopic.php?t=497644
12 team 1PPR: qb, 2wr, 2rb, te, w/r/t, k, d
WR: C.Johnson, M.Austin, T.Y.Hilton, K.Thompkins, P.Harvin
RB: S.Jackson, R.Bush, D.Sproles, A.Bradshaw, B.Tate, Michael Bush