To be safe, I'd probably go with Kolb... Idk, I wouldn't feel safe after Romo's injury, personally.
I like Fred Jackson as well, but the problem is that the consensus is that NE will come out slinging, forcing the Bills to do the same to try and keep up, so not much running will occur. However, it does make sense that if the Bills manage to get a lead somehow, they'll want to start pounding the ball with Jackson. In this situation, Jackson is obviously very good.
Now on to the other Jackson. He is indeed a stud, but my concern is a possible reinjury a la Foster, forcing him to miss more time than if he had just rested another week.
If you don't care much about the negatives, I do feel that both Jacksons have better potential than the safer route of Green-Ellis and Benson.
Help on mine appreciated: viewtopic.php?t=498022