I'd try packaging Reggie Wayne & Shonn Greene/Knowshon Moreno/DeAngelo Williams for an upgrade a WR. You've got a solid squad, but I, like you, would be very nervous having/starting both Reggie Wayne and Dallas Clark on a weekly basis.
If it were me I'd start the deal off with DeAngelo Williams - he hasn't even been the most productive back on the team, and they aren't running the ball at all either. At least last week, Jonathan Stewart was in the game during goal line situations, and Cam Newton is obviously going to vulture plenty of TD's from either running back. If they're not buying DeAngelo Williams I'd move to Shonn Greene. They haven't been able to run the ball as is this season, and with Nick Mangold's injury you've got to be even more concerned.
You've got plenty of flexibility with you're set-up at running back. I'd definitely be starting Ryan Mathews over Knowshon Moreno, and I'd try to package these Colts players to further upgrade your roster across the board. You even have enough RB depth where you could go after the Jamaal Charles owner with several running backs and land another WR1.
I hope some of this was able to help you.
Give me some help on my trade. I could really use some advice: viewtopic.php?f=18&t=498348