Tough, tough, tough. I would avoid Wayne for Week 3 no problem, it's just too much of a gamble. If you have the space to put up a risk, I'd try out Nelson for once. Bowe is an inconsistent receiver playing for a Chiefs offense that is suffering major losses, I just don't see it happening.
10 team H2H league, standard scoring [NFL.com]
QB: A. Rogers
RB: MJD, S. Jax, J. Starks, D. Murray, M. Bush
WR: M. Wallace, B. Marshall, P. Harvin, M. Colston, L. Robinson
TE: O. Daniels, J. Gresham
K: Sebastian Janikowski