Hi there and welcome to the Cafe! It's nice to see a new face around these parts and hope you stick around
As for your questions, they bring up a lot more questions for me, so I'll share mine in the interests of being better informed to help you better in the end (and this information will help others answer any other future questions).
So, what is your: League size, scoring settings, starting requirements, bench players?
Also, as for questions about which players you should pick up, go ahead and post all the pertinent information referenced above, along with a list of available free agents in the Draft, Trade, Keeper and Waivers forum
Hope this helps