I don't wanna sound like I'm just copying haha.
But three people saying the same thing will further ensure your choices.
I'll go Gore and Bradshaw for RB's.
Reason why: Gore and Bradshaw have already shown they can be relied on. Murray had an outstanding week last week. It might be because of the St. Louis defense or might be because he's really good. Who knows, I'd give him another week before starting him to see if he can produce 13+ points on a weekly basis as a starter. I doubt they'll give Jones his starting position after this week.
WR I think is obviously Colston.
Even though it's kind of frustrating because Brees throws it to a variety of receivers and Colston doesn't always bring in TD's. St Louis's defense is atrocious.