TB was very good about limiting Reggie Bush, so I see them doing the same against Sproles. Murray and Tolbert are close. but Id lean towards Tolbert because of his role in the passing game. But if Brinkley plays, I'd switch it up to Murray. Brinkley looked like a beast when Mathews went down and I see him getting a bunch of work if he's cleared to play.
Seattle has a great run defense, believe it or not, so I'd advise against Murray. I don't like Tolbert and don't think that San Diego has been running a lot. Sproles may be a bit inconsistent but not as much as Tolbert. Murray has, well, only played two weeks. I'm still not convinced. Sproles has a ton of total yards on the season and is an uneasy start but a good fast player. Couldn't fault you for starting Murray but I'd go with Sproles
QB Romo & Cutler; RB: R Grant, R Mathews, F Jones, F Jackson. M Tolbert. & C Williams; WR/TE used as same: G Jennings, A Gates, M Austin, S Holmes, D Keller; Kicker: M Crosby. TD League-bonus-100 yds rushing, receiving, & 300 yard passing.