I know Welker hasn't been stellar recently, but I wouldn't sit him over the others.
As for your 2nd WR slot, I'd go Cruz. Main reason is that Brees spreads it around, so I think Cruz has a better chance of putting up big numbers than does Colston. I also think as a Giants fan that they will air it out more than usual since they will be playing from behind.
Help with mine? viewtopic.php?t=509649