I've never been in a ppr league, so this isn't exactly my area of expertise. Anyway, I'd go Cruz, Jones, and Moss for WR and flex. With Revis on Nicks I think Cruz has a big game, Jones will get his chances as the Falcons try to keep up with the Saints, and Moss is very reliable and hauls in a decent amount of catches even if it's not major yardage.
For the RBs, that's tough..
I'd stay away from Jones due to health, and I don't like Lynch against the Niners D. I'd probably say go with Turner and Spiller. Turner isn't very involved in the passing game, but I think this will be a high scoring game and he'll get a chance for a few goal line carries. Good luck.