I'm in 16 men league for years, 4 leagues per year too.
We start QB; 2RB; 3WR; TE; K, DEF with 6BN players. You need 6 players on the bench cause of so many injuries to your RB and to deal with the Bye weeks.
We don't use IDP players, or at least, only one.
You just have to be wise, make trades so you can Manage a good team. There are 32 teams in the NFL, no way you cannot find enough starters.
QB- Tannehill, Weeden, Vick, Henne
RB- A Foster, A Morris, McGahee, Jackson, B Wells, P Thomas, J Rodgers
WR- Cobb, R White, Austin, D Baldwin (Sea)
TE- Witten, Bennett
DEF- SF Ind
Dynasty/16 teams H2H PLAY; 1 QB, 2 RB'S, 3 WR'S, 1 TE, 1 K, 1 D