Steve Smith is a shoo in but the others I have trouble. Even the defense
Marshall in the 4th is about right but on the new team its still uncertain if he will put up the numbers you expect. If he gets back to his old days and catches 100 passes sure Id take him there. But you just dont know. I do have him above Dez though.
Dez is in great shape but always seems hurt and off field incidents dont help him. If he stays out of trouble and healthy i think he could be top 10 but history doesnt show that.
The niners were a solid bunch last year but Defenses are weird by the fact that some of their points are flukes like tipped passes etc. I still have them #1 and in that round its a steal.
If you are set on going with a skill player Id probably take Marshall over Dez but its close. Uncertainty on both ends. The niners in the 16th is not bad though as long as you can fill up with better or equal WR's with the early picks