You have an awesome team. Elite QB, great reciever depth, and a good TE duo. Eli Manning and your starting WR trio will carry you to the playoffs.
If you don't make it far in the playoffs this season, it'll be because of how thin you are at RB. Rice is great, but you're pushing it relying on Frank Gore and DeAngelo as RB's twos. Both have a lot of milage on them and play in crowded back fields.
I'd cut some WR depth - namely the consistently mediocre Robert Meachem - for a waiver wire back - namely Alfred Morris, who I could see exploding - if possible.