Fred Jackson missed the final six games last season with a broken leg. On Sunday, he suffered another leg injury that took him out of the game.
The running back exited the Buffalo Bills' season opener against the New York Jets after suffering a lower leg injury during the first half at MetLife Stadium.
The Bills later announced Jackson wouldn't return.
Jackson took a handoff off right tackle with 11:17 remaining in the second quarter before he was taken down low by Jets safety LaRon Landry. Jackson attempted to walk it off on the Bills' sideline, but he later was seen walking gingerly toward the locker room with two trainers.
C.J. Spiller replaced Jackson and busted a 56-yard touchdown run on his third carry. If Jackson is forced to miss extended time, Spiller could be in position to steal carries once Jackson returns.
UPDATE: Jackson will undergo an MRI to determine the severity of the injury.http://www.nfl.com/news/story/0ap1000000059918/article/fred-jackson-to-undergo-mri-on-injured-knee-bills-say