I think Martin against the Giants. We all saw what Murray did to them, Martin can do that as well. Gore plays a Detroit D that is fairly stout and held Stephen Jackson to less than 60 yards on like 200 carries or something. Gore looked fresh against Green Bay, but we all know he's one stiff breeze away from another injury. I'd go with youth v. a suspect run D.
I would take Wayne v. Minnesota. Seriously, Minnesota let Blaine Gabbert and that superstar Cecil Shorts have their way, I think the #1 pick and one of the top 20 WR in the league can repeat that.