For your QB, I kinda like Fitzpatrick, I think the game should be pretty good for scoring, and he's got some good redzone options. I think he's an even better bet if Jackson or Spiller play.
For the flex I like LeShoure, Minnesota has a good front 7, but they won't be able to stack the box with Calvin on the outside taking safety help. I'm not sure the gamelan for the Vikings is to stop LeShoure, and I do think the Lions will try to keep a balanced attack.
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