I have both Peyton (who is the Manning facing SD) and Luck and will roll with Peyton again this week. You don't say what your scoring system is and how much it favors points over yardage or how much it penalizes for turnovers, but given their respective matchups, I think Peyton's the better choice. Yeah, Revis' absence makes the Jets more vulnerable, but there's a better chance that IND will go up big and throw less, because of the Jets' lack of scoring. I think it's more likely DEN and SD score more and give Peyton more opportunities to come up big.
Help with mine?viewtopic.php?f=19&t=525059
12 team, H2H, Standard Scoring (Starters in bold)
QB: P. Manning, Luck
WR: Julio Jones, Welker, Alexander, Hilton, Shorts
RB: Rice, Wilson, BJGE, LeShoure
DEF: DET, SD