I would stick with SF at home.
The Bills are just terrible, Seattle is pretty good at home and I could see them really moving the chains on the Pats, Bucs are ok against the run but nobody can stop Jamaal Charles, especially when they feed him the ball 30x a game, probably more now that Quinn is starting, ...Miami is really the only other one I would consider considering the lackluster offense they are playing but I still like the 49'ers here by a pretty wide margin.
QB: Drew Brees
RB: Jamaal Charles, Steven Jackson, The Lawfirm, Ben Tate
WR: Steve Smith, Lance Moore, Danario Alexander, Danny Amendola, Pierre Garcon, Anquan Boldin
TE: Heath Miller
DST: vikings, steelers, colts
K: Matt Bryant