Fitzpatrick and Freeman appear to be your best matchup options (though don't discount Palmer's juicy matchup against JAX either...) Here's the difference: Freeman will probably be throwing the whole game in order to try to keep up with Brees. Fitz, on the other hand, will probably get a pretty good lead over crappy TEN and then spend the rest of the game handing off to the 2-headed monster of FJax and CJ. Up to you, but I'm leaning towards Freeman.
I have the same problem (Peyton on bye), but in addition to Fitz, Freeman, and Palmer, I also have Romo at CAR and Luck vs. CLE available. Leaning toward Freeman or Luck. Thoughts?