Okay, so McCoy and Roddy White MUST be in your lineup always, unless they're on a bye-week. Now, you're stuck with Vincent Jackson, which gives you 2 spots with 3 choices: Mathews, Welker, Bradshaw.
I'm actually gonna suggest you go with Mathews and Welker, not Bradshaw. He's questionable for the Cowboys, and Giants running game is pitiful. To quote the Dothraki, "It is known."