Thanks for the help with mine. Man that is tough. I don't like Pitt's D here. They have been struggling against the pass with Taylor out and they have had trouble forcing turnovers and getting sacks. Unless they pitch a shutout I don't see how they can put up that many points. Seattle is the best defense of this bunch for fantasy purposes and they are playing at home where they are really good. The fact that Kaepernick is so mobile and that the 9ers don't turn the ball over much is a challenge however. KC has been terrible on O lately and they are starting a new QB, but Indy's D is bad and there is a risk that Charles goes off.
Seattle is the safest pick here while Indy probably has the highest upside. Unless you think you are going to lose without a huge performance from the D I'd probably go with Seattle (it also helps that they have really good STs).