Is this standard scoring, how many teams?
Definitely pick up Bowell, though if you're not #1 or #2, you may not get him.
You have nice trade bait in Matt Ryan and Dwayne Bowe. Bowe has always been a guy who has more name value than actual fantasy output. Garcon is ok for a #2 WR but something about him just scares me, I don't know if it's his health or RG III's production this year.
I can sympathize with you on Spiller. I believe he will rebound though, maybe not top 5 RB level since they will continue to use Jackson a lot, but not a bomb by drafting him 1st round.
Lamar Miller, disappointment, sure. I'd hope he has another decent game and then trade him. He could be Ryan Matthews 2.0.
Mike Williams, TB and Josh Freeman are in disarray so bad luck there.
All in all, you mainly have bad luck. You lucked out on Peyton no matter what round you drafted him after the 1st. I'd say if you're going to pull trades, do it now if you have Matt Ryan. You're not getting much out of Lamar Miller now. Some owner may still have hope for Ryan Mathews but we know what he is worth by now and his ceiling is already set. Hope that Moreno will have another TD game and use him in a combo trade with Matt Ryan and Ryan Matthews.
If you can get a Doug Martin or an Alfred Morris involving Garcon and Lamar Miller, then great. If not, then gun for a DeMarco Murray and pray.