This year, in 12 team drafts, in order: 8, 4, 10.
I like all of the top 4 RB's about the same, and all of the 5-8 RB's about the same, so ideally I'd like to be at the end of one of those strings. The reason I put 8 over 4 is that I feel the guys going early in round 2 like Henry, Rudi, etc. have more potential value this year than guys in those spots have had in years past, and picking at #8 gives you one of those top 8 RB's plus one of those great value early 2nd rounders.
At 10, you get whoever drops out of Edge/Moss and then a great 2nd round pick.