If I get Tiki, I won't draft Danye.
If I get Henry, I probably won't draft McGahee.
If I get Davis, I will draft Foster.
If I get Faulk, I will draft Gordon.
Interesting post. I usually consider handcuffing to be completely worthless since the majority of the players have never set foot in an NFL game and the handcuff you choose is probably wrong.
Do you handcuff Toefield or Jones to Taylor?
Do you handcuff Taylor or Smith to Lewis?
Do you handcuff Faulk or Cobbs to Dillon?
Who actually handcuffed Domanick Davis to Stacey Mack or Brian Westbrook to Duce Staley last season? How many people wasted a draft pick on Larry Johnson or McGahee last season?
OTOH, I have thought of "handcuffing" RBBC types to each other. Dunn & Duckett, Westbrook & Buckhalter, since more often than not, both players are semi-proven and if one goes down or wins the job outright, you probably get a solid starter.