We debated this topic in Great Debates just recently. Here is the link:
http://www.fantasyfootballcafe.com/foru ... hp?t=66329
Overall, I think a very good point was raised in these debates -- it may be sexy to get Culpepper and Moss, but remember that you'll be taking them with the first two picks in most leagues. This means that you'll be relying on middle round picks to pick you up on weeks that Culpepper and Moss struggle.
However, taking QB/WR combos later in the draft (Pennington/SMoss, Favre/Walker) give you a better chance for success since on big weeks with the combos, you'll kill people. When they have a down week as a duo, you have your first, second and third round picks there picking up the slack.