One word: kick returners.
(Darn it, that was two words.
Seriously though, in this league (just at first glance) I'd:
Try to grab two top-of-the-line RBs (rushing yards do count) who are an important part of their team's passing game.
Take a QB a bit earlier than most other leagues. One who'll pick up a few yards on the ground wouldn't hurt.
Wait on WRs, and grab kick returners later - unless you see other owners picking KRs early. In that case, scrap this plan.
Let others be sneaky and pick the top TEs.
Not worry too much about paying a high pick for the very best defenses, but try to wind up with two decent options.