I'm not sure. You have to ask yourself who's gonna be there at #10. IMO, stud RB's go about 7-8 deep (depending on your rankings and scoring system) before you hit the 2nd tier. At that point you get into the world of Brian Westbrook's, Fred Taylor's and Corey Dillon's. Don't get me wrong, they're great players, but given your scoring system, I think I'd rather go with Culpepper or Manning.
Considering you will likely be able to get a RB of equal value on the snake-around at #15, I'd consider going after a stud QB at #10. I'm sure others would disagree.