I try to anticipate bye weeks during the draft so I don't get stuck. I did fairly well with it, but got stuck during week 3 with Henry and Davis both being off. I was forced to use only Taylor and Lamar Gordon but had 3 solid WRs (Wayne, Jackson and Mason) to make up the difference. I made sure I had strength at another position for a flex start to cover my backside (believe it or not, I won in week 3 with those 2 Rbs).
Also, max out the ww. If you have enough bench spots and your league isn't too deep (ours is 10 team), then you can usually find a couple hidden gems there or guys to take a flier on. My ww. pickups so far have been Gordon (dropped), Wayne, Pittman, Daniel Graham, Falcons D, Gannon (dropped), Warner, Pinner. I'm hoping this week to pick up Chester Taylor and Plax, Morton or Evans. Depending on Vandy's situation, I may have to pick up a kicker.
I have not had to make one single trade so far and none of my guys have buys this week, but I have a guy in my league who lost Garner a week ago and now has Holmes and TJones on bye weeks. This is the point where some guys will have to get desperate enough to trade or suck it up and take the loss, hoping to make it up in later weeks. If you are 4-0 or 3-1 at this point and playing the league cream-puff, don't make any trades you'll regret. If you are below .500, take some chances.
Luck has played into it, too, where my guys have been relatively healthy and I can trade because I choose to, not because I have to. Believe me, that's the best situation to be in. Let everyone else be desperate.