SF+10 is an easy and obvious choice to me. The Jets are good, but not 10 point deficit good.
Miami/Buff has far too many variables. Miami's D will undoubtedly crush Bledsoe. Repeatedly. Miami's O on the other hand will be terrible. Further, with Travis Henry sporting a big fat "Q" on the injury report.. well, it raises the question on whether you're up to balancing McGahee's talent v. the fact that it could be his first NFL start against a highly rated defense.
Miami also ends every season with a winning record. Even in the shoddy state they're in, I fully expect them to approach the .500 mark, and I can deffinately see them fighting the bills tooth and nail for a win. This game is just way too iffy to bet on.